LOXL1 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human LOXL1 protein.
Immunogen
LOXL1 (NP_005567.2, 1 a.a. ~ 574 a.a) full-length human protein.
Sequence
MALARGSRQLGALVWGACLCVLVHGQQAQPGQGSDPARWRQLIQWENNGQVYSLLNSGSEYVPAGPQRSESSSRVLLAGAPQAQQRRSHGSPRRRQAPSLPLPGRVGSDTVRGQARHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSVSASAFASTYRQQPSYPQQFPYPQAPFVSQYENYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVIYPYQPRARYEEYGGGEELPEYPPQGFYPAPERPYVPPPPPPPDGLDRRYSHSLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYANPPPEAYGPPRALEPPYLPVRSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSATNCKIVQS
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (84)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of LOXL1 expression in transfected 293T cell line (H00004016-T01) by LOXL1 MaxPab polyclonal antibody.
Lane 1: LOXL1 transfected lysate(63.10 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to LOXL1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — LOXL1
Entrez GeneID
4016GeneBank Accession#
NM_005576.2Protein Accession#
NP_005567.2Gene Name
LOXL1
Gene Alias
LOL, LOXL
Gene Description
lysyl oxidase-like 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq
Other Designations
lysyl oxidase homolog 1
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Interactome
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Disease
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Publication Reference
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Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
Qingjiang Hu, Takaaki Masuda, Shotaro Kuramitsu, Taro Tobo, Kuniaki Sato, Shinya Kidogami, Sho Nambara, Masami Ueda, Yusuke Tsuruda, Yosuke Kuroda, Shuhei Ito, Eiji Oki, Masaki Mori, Koshi Mimori.
PLoS One 2020 Oct; 15(10):e0241140.
Application:IHC-P, WB-Tr, Human, AGS cells, Human gastric cancer.
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Gremlin Utilizes Canonical and Non-Canonical TGFβ Signaling to Induce Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells.
Sethi A, Wordinger RJ, Clark AF.
Experimental Eye Research 2013 Aug; 113:117.
Application:WB-Ce, Human, TM cells.
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Transforming Growth Factor Beta Induces Extracellular Matrix Protein Crosslinking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells.
Sethi A, Mao W, Wordinger RJ, Clark AF.
Invest Ophthalmol Vis Sci 2011 May; 52:5240.
Application:WB-Ce, Human, Trabecular meshwork cells.
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Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.
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