KPNA2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: KPNA2 transfected lysate ( 57.9 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
KPNA2 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-KPNA2 full-length
Host
Human
Theoretical MW (kDa)
58.3
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-KPNA2 antibody (H00003838-B01) by Western Blots.
Western Blot
Lane 1: KPNA2 transfected lysate ( 57.9 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
KPNA2 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — KPNA2
Entrez GeneID
3838GeneBank Accession#
NM_002266Protein Accession#
NP_002257Gene Name
KPNA2
Gene Alias
IPOA1, QIP2, RCH1, SRP1alpha
Gene Description
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Omim ID
600685Gene Ontology
HyperlinkGene Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
Other Designations
RAG cohort 1|importin alpha 1|importin alpha 2|importin-alpha-P1|karyopherin alpha 2|pendulin
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Interactome
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Disease
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