GLA (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human GLA full-length ORF ( AAH02689, 1 a.a. - 429 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
72.93
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GLA
Entrez GeneID
2717GeneBank Accession#
BC002689Protein Accession#
AAH02689Gene Name
GLA
Gene Alias
GALA
Gene Description
galactosidase, alpha
Gene Ontology
HyperlinkGene Summary
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq
Other Designations
OTTHUMP00000023679|agalsidase alfa|alpha-D-galactosidase A|alpha-D-galactoside galactohydrolase 1|alpha-gal A|alpha-galactosidase A|melibiase
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Interactome
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Pathway
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Disease
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Publication Reference
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Integrated approach to produce a recombinant, his-tagged human alpha-galactosidase A in mammalian cells.
Corchero JL, Mendoza R, Lorenzo J, Rodriguez-Sureda V, Dominguez C, Vazquez E, Ferrer-Miralles N, Villaverde A.
Biotechnology Progress 2011 Sep; 27(5):1206.
Application：WB, Rabbit, Serum.
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Integrated approach to produce a recombinant, his-tagged human alpha-galactosidase A in mammalian cells.
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