FKBP1B monoclonal antibody (M01), clone 4H5-1B6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant FKBP1B.
Immunogen
FKBP1B (AAH02614, 1 a.a. ~ 80 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQLGPLSPLPICPHPC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (97)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (34.54 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of FKBP1B expression in transfected 293T cell line by FKBP1B monoclonal antibody (M01), clone 4H5-1B6.
Lane 1: FKBP1B transfected lysate(11.8 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — FKBP1B
Entrez GeneID
2281GeneBank Accession#
BC002614Protein Accession#
AAH02614Gene Name
FKBP1B
Gene Alias
FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
Gene Description
FK506 binding protein 1B, 12.6 kDa
Omim ID
600620Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq
Other Designations
FK506-binding protein 1-like|FK506-binding protein 12.6|OTTHUMP00000116040|OTTHUMP00000116041|calstabin 2|immunophilin FKBP12.6|peptidyl-prolyl cis-trans isomerase|rotamase
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Interactome
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Disease
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Publication Reference
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Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6.
Kafa Walweel, Nicole Beard, Dirk F van Helden, Derek R Laver.
The Journal of General Physiology 2023 Jun; 155(8):e202213277.
Application:Stimulation, Sheep, Sheep heart.
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Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6.
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