CYBB DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human CYBB DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — CYBB
Entrez GeneID
1536GeneBank Accession#
NM_000397.2Protein Accession#
NP_000388.2Gene Name
CYBB
Gene Alias
CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX
Gene Description
cytochrome b-245, beta polypeptide
Gene Ontology
HyperlinkGene Summary
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq
Other Designations
OTTHUMP00000031915|cytochrome b-245 beta polypeptide
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Interactome
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Pathway
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Disease
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