EWSR1/ATF1 Translocation FISH Probe
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: EWSR1
Size: Approximately 1200kb
Fluorophore: FITC
Location: 22q12Probe 2
Name: ATF1
Size: Approximately 840kb
Fluorophore: Texas Red
Location: 12q13.12Origin
Human
Source
Genomic DNA
Reactivity
Human
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulatory Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
-
Applications
Fluorescent In Situ Hybridization (Cell)
-
Gene Info — ATF1
-
Gene Info — EWSR1
Entrez GeneID
2130Gene Name
EWSR1
Gene Alias
EWS
Gene Description
Ewing sarcoma breakpoint region 1
Omim ID
133450Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq
Other Designations
Ewings sarcoma EWS-Fli1 (type 1) oncogene|bK984G1.4 (Ewing sarcoma breakpoint region 1 protein)
-
Interactome
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com