PDGFRA/CEN4p FISH Probe
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: PDGFRA
Size: Approximately 240kb
Fluorophore: Texas Red
Location: 4q12Probe 2
Name: CEN4p
Size: Approximately 560kb
Fluorophore: FITC
Location: 4p13Probe Gap
The gap between two probes is approximately 9200 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
-
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung squamous cell carcinoma (FFPE) stained with PDGFRA/CEN4p FISH Probe. Human lung squamous cell carcinoma showed no PDGFRA gene amplification. -
Gene Info — PDGFRA
Entrez GeneID
5156Gene Name
PDGFRA
Gene Alias
CD140A, MGC74795, PDGFR2, Rhe-PDGFRA
Gene Description
platelet-derived growth factor receptor, alpha polypeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq
Other Designations
FIP1L1/PDGFRA fusion protein|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients.
Leiss L, Mega A, Olsson Bontell T, Nistér M, Smits A, Corvigno S, Rahman MA, Enger PØ, Miletic H, Östman A.
Glia 2020 May; 68(5):979.
Application:FISH, Human, Human glioblastoma cells.
-
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pages M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA.
Acta Neuropathologica 2015 Dec; 130(6):815.
Application:FISH, Human, Gliomas.
-
Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com