PML FISH Probe

Catalog # FA0349

Size

Price

Stock

Quantity

Size:200 uL
Price: USD $ 2,585.00
Stock:
made to order, 3 weeks
abnova-minus
abnova-plus

* The price is valid only in USA. Please select country.

Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
  • Specification

    Product Description

    Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).

    Origin

    Human

    Source

    Genomic DNA

    Reactivity

    Human

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulation Status

    For research use only (RUO)

    Supplied Product

    DAPI Counterstain (1500 ng/mL ) 250 uL

    Storage Instruction

    Store at 4°C in the dark.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

  • Gene Info — PML

    Entrez GeneID

    5371

    Gene Name

    PML

    Gene Alias

    MYL, PP8675, RNF71, TRIM19

    Gene Description

    promyelocytic leukemia

    Omim ID

    102578

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

    Other Designations

    promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19

  • Interactome
  • Pathway
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
4 Products to Compare
Remove All