IL13 (Human) Recombinant Protein
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Specifications
Product Description
Human IL13 (P35225, 19 a.a. -132 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
SPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN
Host
Escherichia coli
Theoretical MW (kDa)
13
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Activity
The ED50 was determined by the dose-dependent proliferation of TF-1 cells was <= 2.0 ng/mL, corresponding to a specific activity of >= 1 x 106 units/mg.
Storage Buffer
Lyophilized from PBS, pH 7.2
Storage Instruction
Store at -20°C on dry atmosphere for 2 years.
After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL13
Entrez GeneID
3596Protein Accession#
P35225Gene Name
IL13
Gene Alias
ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600
Gene Description
interleukin 13
Gene Ontology
HyperlinkGene Summary
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq
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