MME monoclonal antibody, clone CB-CALLA
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Specification
Product Description
Mouse monoclonal antibody raised against full length native MME.
Immunogen
Native pufiried MME from human B-lineage leukemia cells.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to MME.
Form
Liquid
Isotype
IgG2b
Recommend Usage
Flow cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In BBS, pH8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — MME
Entrez GeneID
4311Gene Name
MME
Gene Alias
CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP
Gene Description
membrane metallo-endopeptidase
Omim ID
120520Gene Ontology
HyperlinkGene Summary
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
Other Designations
atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase
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Interactome
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Pathway
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Disease
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Publication Reference
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Neutral endopeptidase modulation of septic shock.
Lu B, Gerard NP, Kolakowski LF Jr, Bozza M, Zurakowski D, Finco O, Carroll MC, Gerard C.
The Journal of Experimental Medicine 1995 Jun; 181(6):2271.
Application:WB-Ti, Mouse, Mouse kidneys.
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Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key!
Shipp MA, Look AT.
Blood 1993 Aug; 82(4):1052.
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Neutral endopeptidase modulation of septic shock.
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