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Western Blot

Immunofluorescence

Immunofluorescent staining of Jurkat cells with MME recombinant monoclonal antibody, clone NL-1 (Cat # RAB03151).
Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells on Shi-fix™ coverslips- permewith 0.15% Triton and stained with the chimeric r version of RAB03151 at 10 ug/ml for 1h followed by Alexa Fluor® 488 secondary antibody (1 ug/ml)- showing punctate cytoplasmic staining- likely from protein trafficking vesicles. The nuclear stain is DAPI (blue). The isotype control was stained with an anti-Fluorescein antibody (0) followed by Alexa Fluor® 488 secondary antibody.

Immunoprecipitation

Entrez GeneID

4311

Gene Name

MME

Gene Alias

CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP

Gene Description

membrane metallo-endopeptidase

Omim ID

120520

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq

Other Designations

atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase