MME monoclonal antibody, clone MEM-78 (PE)
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More Files
- More Functions
Flow Cytometry
Surface staining of NALM-6 (human pre-B cell leukemia cell line) with MME monoclonal antibody, clone MEM-78 (PE) (Cat # MAB4606). Total viable cells were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against native MME.
Immunogen
Native purified MME from NALM-6 human pre-B cell line.
Host
Mouse
Theoretical MW (kDa)
100
Reactivity
Human
Specificity
This antibody reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 KDa type II integral membrane protein.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of NALM-6 (human pre-B cell leukemia cell line) with MME monoclonal antibody, clone MEM-78 (PE) (Cat # MAB4606). Total viable cells were used for analysis. -
Gene Info — MME
Entrez GeneID
4311Gene Name
MME
Gene Alias
CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP
Gene Description
membrane metallo-endopeptidase
Omim ID
120520Gene Ontology
HyperlinkGene Summary
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
Other Designations
atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential expression of CD10 in prostate cancer and its clinical implication.
Dall'Era MA, True LD, Siegel AF, Porter MP, Sherertz TM, Liu AY.
BMC Urology 2007 Mar; 7:3.
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CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression.
Braham H, Trimeche M, Ziadi S, Mestiri S, Mokni M, Amara K, Hachana M, Sriha B, Korbi S.
Virchows Archiv : an International Journal of Pathology 2006 May; 449(2):220.
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Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74).
Horejsí V, Angelisová P, Bazil V, Kristofová H, Stoyanov S, Stefanová I, Hausner P, Vosecký M, Hilgert I.
Folia Biol (Praha) 1988 Jan; 34(1):23.
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Differential expression of CD10 in prostate cancer and its clinical implication.
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