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Last updated: 2014/9/15
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MME monoclonal antibody, clone MEM-78 (PE)

  • Catalog # : MAB4606
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native MME.
  • Immunogen:
  • Native purified MME from NALM-6 human pre-B cell line.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 100
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 KDa type II integral membrane protein.
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.2% BSA, 15 mM sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Surface staining of NALM-6 (human pre-B cell leukemia cell line) with MME monoclonal antibody, clone MEM-78 (PE) (Cat # MAB4606). Total viable cells were used for analysis.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 4311
  • Gene Name:
  • MME
  • Gene Alias:
  • CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP
  • Gene Description:
  • membrane metallo-endopeptidase
  • Gene Summary:
  • This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
  • Other Designations:
  • atriopeptidase,common acute lymphocytic leukemia antigen,enkephalinase,membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase),membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10),membrane metallo-endopeptidase
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