HNRNPK monoclonal antibody, clone F45 P9 C7
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of HNRNPK.
Immunogen
A synthetic peptide corresponding to C-terminus of human HNRNPK.
Host
Mouse
Reactivity
Chicken, Human, Mouse, Rabbit, Rat
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot using HNRNPK monoclonal antibody, clone F45 P9 C7 (Cat # MAB1891) on Calu-6 (1) and HT-29 (2) cell lysates.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — HNRNPK
Entrez GeneID
3190Gene Name
HNRNPK
Gene Alias
CSBP, FLJ41122, HNRPK, TUNP
Gene Description
heterogeneous nuclear ribonucleoprotein K
Omim ID
600712Gene Ontology
HyperlinkGene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq
Other Designations
OTTHUMP00000021554|OTTHUMP00000021557|OTTHUMP00000021558|dC-stretch binding protein|transformation upregulated nuclear protein
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Interactome
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Publication Reference
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Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer.
Carpenter B, McKay M, Dundas SR, Lawrie LC, Telfer C, Murray GI.
British Journal of Cancer 2006 Oct; 95(7):921.
Application:IHC, WB, Human, HT-29 cells, Human colorectal cancer.
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Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells.
Wei CC, Zhang SL, Chen YW, Guo DF, Ingelfinger JR, Bomsztyk K, Chan JS.
The Journal of Biological Chemistry 2006 Sep; 281(35):25344.
Application:ChIP, WB, Rat, Rat renal proximal tubular cells.
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The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin.
Dzwonek A, Mikula M, Ostrowski J.
FEBS Letters 2006 Mar; 580(7):1839.
Application:WB, Rat, HTC-IR cells.
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Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer.
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