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Last updated: 2014/7/21

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YWHAE Split FISH Probe

  • Catalog # : FS0021
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FS0021
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome:

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • YWHAE(TexRed)
    Approximately 460kb
    Texas Red
    17q13.3
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • YWHAE(FITC)
    Approximately 780kb
    FITC
    17q13.3
  • Probe Gap:
  • The gap between two probes is approximately 25 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human breast cancer (FFPE) stained with YWHAE Split FISH Probe. Human breast cancer showed YWHAE gene split.
  • Protocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7531
  • Gene Name:
  • YWHAE
  • Gene Alias:
  • 14-3-3E,FLJ45465,KCIP-1,MDCR,MDS
  • Gene Description:
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Gene Summary:
  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq
  • Other Designations:
  • 14-3-3 epsilon,mitochondrial import stimulation factor L subunit,protein kinase C inhibitor protein-1,tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
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