ATF2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
ATF2 polyclonal antibody (Cat # PAB6063) staining (0.5 ug/mL) of human placenta lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ATF2.
Immunogen
A synthetic peptide corresponding to human ATF2.
Sequence
C-IVMAPSSQSQPSGS
Host
Goat
Theoretical MW (kDa)
54.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ATF2 polyclonal antibody (Cat # PAB6063) staining (0.5 ug/mL) of human placenta lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ATF2
Entrez GeneID
1386Protein Accession#
NP_001871.2Gene Name
ATF2
Gene Alias
CRE-BP1, CREB2, HB16, MGC111558, TREB7
Gene Description
activating transcription factor 2
Omim ID
123811Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000163262|activating transcription factor 2 splice variant ATF2-var2|cAMP responsive element binding protein 2, formerly
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Interactome
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Pathway
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Disease
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Publication Reference
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Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, Ishii S, Yazaki Y, Nagai R, Komuro I.
The Journal of Cell Biology 2001 May; 153(4):687.
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Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
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