DNMT1 (phospho S154) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of DNMT1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S154 of human DNMT1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of DNMT1 (phospho S154) polyclonal antibody (Cat # PAB4924) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — DNMT1
Entrez GeneID
1786Protein Accession#
NP_001370;P26358Gene Name
DNMT1
Gene Alias
AIM, CXXC9, DNMT, FLJ16293, MCMT, MGC104992
Gene Description
DNA (cytosine-5-)-methyltransferase 1
Omim ID
126375Gene Ontology
HyperlinkGene Summary
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CXXC finger protein 9|DNA methyltransferase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Liao X, Siu MK, Chan KY, Wong ES, Ngan HY, Chan QK, Li AS, Khoo US, Cheung AN.
International Journal of Cancer 2008 Jul; 123(2):296.
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Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers.
Leng S, Stidley CA, Bernauer AM, Picchi MA, Sheng X, Frasco MA, Van Den Berg D, Gilliland FD, Crowell RE, Belinsky SA.
Carcinogenesis 2008 May; 29(7):1380.
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Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
Dion V, Lin Y, Hubert L Jr, Waterland RA, Wilson JH.
Human Molecular Genetics 2008 Feb; 17(9):1306.
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Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
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