Western blot using TLR2 polyclonal antibody (Cat # PAB11280) shows detection of TLR2 in A-20 whole cell lysate in the presence (A) and absence (B) of blocking peptide. The membrane was probed with the primary antibody diluted to 1 : 1000.
Immunohistochemistry using TLR2 polyclonal antibody (Cat # PAB11280) shows staining of TLR2 in human spleen cells. The paraffin embedded formalin fixed tissue was reacted with the primary antibody diluted to 1:500.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq