ATF2 (phospho S322) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ATF2.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S322 of human ATF2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of ATF2 (phospho S322) polyclonal antibody (Cat # PAB0410) and ATF2 Non Phospho-specific Pab on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. -
Gene Info — ATF2
Entrez GeneID
1386Protein Accession#
NP_001871;P15336Gene Name
ATF2
Gene Alias
CRE-BP1, CREB2, HB16, MGC111558, TREB7
Gene Description
activating transcription factor 2
Omim ID
123811Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000163262|activating transcription factor 2 splice variant ATF2-var2|cAMP responsive element binding protein 2, formerly
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Publication Reference
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Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1.
Kravets A, Hu Z, Miralem T, Torno MD, Maines MD.
The Journal of Biological Chemistry 2004 Feb; 279(19):19916.
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Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid.
Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J.
The Journal of Biological Chemistry 2004 Jan; 279(17):16996.
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Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.
Averous J, Bruhat A, Jousse C, Carraro V, Thiel G, Fafournoux P.
The Journal of Biological Chemistry 2003 Dec; 279(7):5288.
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Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1.
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