TNFRSF10A monoclonal antibody, clone 32A1380
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of 15 ug of total cell lysate from Daudi cells with TNFRSF10A monoclonal antibody, clone 32A1380 (Cat # MAB0054) at 2 ug/mL .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of TNFRSF10A.
Immunogen
A synthetic peptide corresponding to amino acids 1-20 of human TNFRSF10A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 15 ug of total cell lysate from Daudi cells with TNFRSF10A monoclonal antibody, clone 32A1380 (Cat # MAB0054) at 2 ug/mL .Immunocytochemistry
Immunofluorescence
Flow Cytometry
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Gene Info — TNFRSF10A
Entrez GeneID
8797Gene Name
TNFRSF10A
Gene Alias
APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Gene Description
tumor necrosis factor receptor superfamily, member 10a
Omim ID
603611Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq
Other Designations
TNF-related apoptosis inducing ligand receptor 1|cytotoxic TRAIL receptor|death receptor 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL.
Bui HTT, Le NH, Le QA, Kim SE, Lee S, Kang D.
International Journal of Medical Sciences 2019 Sep; 16(11):1412.
Application：WB-Ce, Human, Human gastric cancer cells, SNU-216 cells.
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4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.
Kroll TM, Bommiasamy H, Boissy RE, Hernandez C, Nickoloff BJ, Mestril R, Caroline Le Poole I.
The Journal of Investigative Dermatology 2005 Apr; 124(4):798.
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Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle.
Ren YG, Wagner KW, Knee DA, Aza-Blanc P, Nasoff M, Deveraux QL.
Molecular Biology of the Cell 2004 Sep; 15(11):5064.
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p53 upregulates death receptor 4 expression through an intronic p53 binding site.
Liu X, Yue P, Khuri FR, Sun SY.
Cancer Research 2004 Aug; 64(15):5078.
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Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation.
Shigeno M, Nakao K, Ichikawa T, Suzuki K, Kawakami A, Abiru S, Miyazoe S, Nakagawa Y, Ishikawa H, Hamasaki K, Nakata K, Ishii N, Eguchi K.
Oncogene 2003 Mar; 22(11):1653.
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Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling.
Chen X, Kandasamy K, Srivastava RK.
Cancer Research 2003 Mar; 63(5):1059.
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Evidence that the human death receptor 4 is regulated by activator protein 1.
Baoxiang Guan, Ping Yue, Reuben Lotan, Shi-Yong Sun.
Oncogene 2002 May; 21(20):3121.
Application：WB-Ce, Human, H1792, PC-3 cells.
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Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells.
J D Bretz, E Mezosi, T J Giordano, P G Gauger, N .W Thompson, J R Baker Jr.
Cell Death and Differentiation 2002 Mar; 9(3):274.
Application：Flow Cyt, WB-Ce, Human, Human thyroid cells.
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Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand.
Ganwei Lu, Bratislav M Janjic, Jelena Janjic, Theresa L Whiteside, Walter J Storkus, Nikola L Vujanovic.
Journal of Immunology 2002 Feb; 168(4):1831.
Application：Blocking, Flow Cyt, Human, Monocyte-derived immature dendritic cells, PCI-13 SCCHN cells.
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Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.
Krishnamoorthy B, Darnay B, Aggarwal B, Dinh DH, Kouraklis G, Olivero WC, Gujrati M, Rao JS.
Clinical Cancer Research 2001 Dec; 7(12):4195.
Application：Flow Cyt, Human, SNB19 glioma cells.
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Differential expression of members of the tumor necrosis factor alpha-related apoptosis-inducing ligand pathway in prostate cancer cells.
Sridhar S, Ali AA, Liang Y, El Etreby MF, Lewis RW, Kumar MV.
Cancer Research 2001 Oct; 61(19):7179.
Application：WB-Ce, WB-Tr, Human, LNCaP, LNCaP C4-2 cells.
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Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL.
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