Orthotopic Xenograft Tumor Models

Various mouse models have been developed and widely exploited in cancer research. To evaluate the efficacy of cancer treatments in preclinical and clinical studies, human tumor xenograft models whereby human cell lines are transplanted into immunocompromized mice are commonly used. In particular, orthotopically implantation of human tumor cells into the equivalent mouse organ where the cancer originated is preferred for demonstrating the effects of new cancer drugs on specific tumors because it provides tumor cells a microenvironment for organotypic interaction which may affect tumor growth, differentiation and its response to drugs. Orthotopic tumor models offer more clinical relevance for tissue site-specific pathology and hence provide prospective evaluation for chemotherapeutic drugs.

With superior skills, Abnova has successfully established several orthotopic human tumor models for researchers to evaluate in vivo efficacy of new compounds for cancer therapy, and more orthotopic models for 8 most common human cancers are in development. With a luciferase expressing cell line directly injected into relevant organ of a live mouse, the orthotopically implanted tumor cells can be easily detected and the growth of tumor in response to anticancer compounds can be monitored in vivo with the IVIS® biophostonic imaging system. Besides providing orthotopic mouse models for different cancers, we also offer customized drug injection service for the convenience of our customers.