Anti-Pembrolizumab polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against Pembrolizumab.
Target gene is PD-1.Immunogen
Pembrolizumab.
Host
Rabbit
Specificity
The product is specific for Pembrolizumab. This antibody serves as an excellent positive control for Pembrolizumab immunogenicity (ADA) assays.
Form
Lyophilized
Preparation Method
This antibody is produced from sera of a rabbit immunized with Pembrolizumab.
Purification
Antigen affinity purification
Recommend Usage
ELISA (ELISA detection: 0.01-0.1 ug/mL) (Direct ELISA)
Immunogenicity assay
The optimal working dilution should be determined by the end user.Inhibitory IC50
N/A
Storage Buffer
Lyophilized from PBS, pH 7.4 (0.02% sodium azide).
Storage Instruction
Store at -20°C on dry atmospher. The lyophilized product remains stable up to 1 year at -20°C from date of receipt.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
ELISA binding of Anti-Pembrolizumab polyclonal antibody (Cat # PAB31787) with Pembrolizumab. Coating antigen: Pembrolizumab, 1 ug/mL. Anti-Pembrolizumab polyclonal antibody (Cat # PAB31787) dilutions start from 1000 ng/mL. EC50 = 21.57 ng/mL.Immunogenicity assay
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Gene Info — PDCD1
Entrez GeneID
5133Gene Name
PDCD1
Gene Alias
CD279, PD1, SLEB2, hPD-1, hPD-l
Gene Description
programmed cell death 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq
Other Designations
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Interactome
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