AIRE polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AIRE.
Immunogen
A synthetic peptide corresponding to human AIRE.
Host
Rabbit
Theoretical MW (kDa)
60
Reactivity
Human, Mouse
Specificity
AIRE polyclonal antibody detects endogenous levels of AIRE protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 293 cell lysate with AIRE polyclonal antibody (Cat # PAB27146).Immunofluorescence
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Gene Info — AIRE
Entrez GeneID
326Protein Accession#
O43918Gene Name
AIRE
Gene Alias
AIRE1, APECED, APS1, APSI, PGA1
Gene Description
autoimmune regulator
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq
Other Designations
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
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Interactome
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Pathway
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Disease
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