CASP1 monoclonal antibody (M01), clone 3D2
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CASP1.
Immunogen
CASP1 (AAH62327, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (54)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CASP1 expression in transfected 293T cell line by CASP1 monoclonal antibody (M01), clone 3D2.
Lane 1: CASP1 transfected lysate(35 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to CASP1 on formalin-fixed paraffin-embedded human hepatocellular carcinoma. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CASP1 is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — CASP1
Entrez GeneID
834GeneBank Accession#
BC062327Protein Accession#
AAH62327Gene Name
CASP1
Gene Alias
ICE, IL1BC, P45
Gene Description
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Omim ID
147678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
CASP1 nirs variant 1|IL1B-convertase|caspase 1|caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)|interleukin 1-B converting enzyme|interleukin 1-beta convertase
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Interactome
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Pathway
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Disease
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