


KLRK1 (Human) Recombinant Protein

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Specifications
Product Description
Human KLRK1 (P26718, Phe78-Val216) partial recombinant protein with hFc-Flag tag at N-terminus expressed in HEK293 cells.
Sequence
Phe78-Val216
Host
Human
Theoretical MW (kDa)
43.4
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Quality Control Testing
SEC-HPLC
Tris-Bis PAGE
Human NKG2D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
SEC-HPLC
The purity of Human NKG2D is greater than 95% as determined by SEC-HPLC.
SEC-HPLC
The purity of Human NKG2D is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human NKG2D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SEC-HPLC
Tris-Bis PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from filtered solution in PBS, pH 7.4 (5% trehalose).
Storage Instruction
After reconstitution with deionized water to a final concentration more than 100 ug/ml, store at 4°C for 1 week. For long term storage, store at -80°C for 1 year.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Inhibition Assay
Serial dilutions of Anti-NKG2D Antibody, hFc Tag were added into Biotinylated Human ULBP-2, His Tag : Human NKG2D, hFc Tag binding reactioins. The half maximal inhibitiory concentration (IC50) is 45.2 ng/ml.Functional Study
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Gene Info — KLRK1
Entrez GeneID
22914Protein Accession#
P26718Gene Name
KLRK1
Gene Alias
CD314, D12S2489E, FLJ17759, FLJ75772, KLR, NKG2-D, NKG2D
Gene Description
killer cell lectin-like receptor subfamily K, member 1
Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. [provided by RefSeq
Other Designations
NK cell receptor D|NKG2-D type II integral membrane protein
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Interactomes
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