

LRRC32/TGFB1 (Human) Recombinant Protein

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Specifications
Product Description
Human LRRC32/TGFB1 (Q14392/P01137, His20-Leu628/Leu30-Ser390) partial recombinant protein with His-Avi tag at C-terminus expressed in HEK293 cells.
Sequence
His20-Leu628;Leu30-Ser390
Host
Human
Theoretical MW (kDa)
70.3
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Quality Control Testing
SEC-HPLC
SEC-HPLC
The purity of Human GARP&Latent TGF Beta 1 Complex is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human GARP&Latent TGF Beta 1 Complex on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SEC-HPLC
Tris-Bis PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from filtered solution in PBS, pH 7.4 (5% trehalose).
Storage Instruction
After reconstitution with deionized water to a final concentration more than 100 ug/ml, store at 4°C for 1 week. For long term storage, store at -80°C for 1 year.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human GARP&Latent TGF Beta 1 Complex, His Tag at 5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-GARP&TGF beta 1 Antibody, hFc Tag with the EC50 of 13.2 ng/ml determined by ELISA.Functional Study
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Gene Info — LRRC32
Entrez GeneID
2615Protein Accession#
Q14392;P01137Gene Name
LRRC32
Gene Alias
D11S833E, GARP
Gene Description
leucine rich repeat containing 32
Omim ID
137207Gene Ontology
HyperlinkGene Summary
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq
Other Designations
garpin|glycoprotein A repetitions predominant
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Gene Info — TGFB1
Entrez GeneID
7040Protein Accession#
Q14392;P01137Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Interactomes
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Pathways
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Diseases
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