

IFNGR1 (Human) Recombinant Protein

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Specifications
Product Description
Human IFNGR1 (AAH05333, Glu18-Gly245) partial recombinant protein with hFc tag at C-terminus expressed in HEK293 cells.
Sequence
Glu18-Gly245
Host
Human
Theoretical MW (kDa)
52.4 kDa
Due to gForm
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human IFN gamma R1 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IFNGR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
Tris-Bis PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from filtered solution in PBS, pH 7.4 (8% trehalose).
Storage Instruction
After reconstitution with deionized water to a final concentration more than 100 ug/ml, store at 4°C for 1 week. For long term storage, store at -80°C for 1 year.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IFN gamma, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human IFN gamma R1, hFc Tag with the EC50 of 2.8ng/ml determined by ELISA.Functional Study
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Gene Info — IFNGR1
Entrez GeneID
3459Protein Accession#
AAH05333Gene Name
IFNGR1
Gene Alias
CD119, FLJ45734, IFNGR
Gene Description
interferon gamma receptor 1
Gene Ontology
HyperlinkGene Summary
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq
Other Designations
AVP, type 2|CD119 antigen|OTTHUMP00000017285|antiviral protein, type 2|immune interferon receptor 1|interferon-gamma receptor alpha chain
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Interactomes
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Pathways
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Diseases
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