NOTCH2 monoclonal antibody, clone B6
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against NOTCH2.
Antibody Species
Mouse
Immunogen
Originate antibody is raised against NRR of mouse Notch 2.
Reactivity
Human, Mouse
Specificity
This engineered ScFv fragment antibody reacts to both mouse mNRR2 and human hNRR2, but not NRR1.
Form
Liquid
Purification
Protein A affinity purified
Isotype
Mouse IgG1, kappa
Recommend Usage
Immunofluorescence
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% Proclin 300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunofluorescence
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Gene Info — NOTCH2
Entrez GeneID
4853Protein Accession#
Q04721|O35516Gene Name
NOTCH2
Gene Alias
AGS2, hN2
Gene Description
Notch homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq
Other Designations
OTTHUMP00000014035|OTTHUMP00000059536|notch 2
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Gene Info — Notch2
Entrez GeneID
18129Protein Accession#
Q04721|O35516Gene Name
Notch2
Gene Alias
AI853703, N2
Gene Description
Notch gene homolog 2 (Drosophila)
Gene Ontology
HyperlinkOther Designations
Motch B|Notch gene homolog 2
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Interactome
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Pathway
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Disease
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