CFL1 polyclonal antibody
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More Files
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Immunofluorescence
Immunocytochemical labeling in chick dorsal root ganglion neurons using CFL1 polyclonal antibody (Cat # PAB7882) . (Images provided by Dr. Diane Snow, Department of Anatomy & Neurobiology, University of Kentucky).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CFL1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CFL1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence has 100% homology with similar regions of rat and mouse Cofilin 1, and has 3 amino acid differences from human Cofilin 2.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Immunocytochemistry (1:50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Immunocytochemical labeling in chick dorsal root ganglion neurons using CFL1 polyclonal antibody (Cat # PAB7882) . (Images provided by Dr. Diane Snow, Department of Anatomy & Neurobiology, University of Kentucky).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CFL1
Entrez GeneID
1072Protein Accession#
P23528Gene Name
CFL1
Gene Alias
CFL
Gene Description
cofilin 1 (non-muscle)
Omim ID
601442Gene Ontology
HyperlinkGene Summary
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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The ADF/cofilin family: actin-remodeling proteins.
Maciver SK, Hussey PJ.
Genome Biology 2002 Apr; 3(5):reviews300.
Application：WB, Human, Mammalian cells.
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Proteins of the ADF/cofilin family: essential regulators of actin dynamics.
Bamburg JR.
Annual Review of Cell and Developmental Biology 1999 Nov; 15:185.
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The ADF/cofilin family: actin-remodeling proteins.
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