CDKN1B polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CDKN1B.
Immunogen
A synthetic peptide corresponding to human CDKN1B.
Sequence
C-KRPATDDSSTQNK
Host
Goat
Theoretical MW (kDa)
22.1
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CDKN1B polyclonal antibody (Cat # PAB6973) (0.1 ug/mL) staining of human prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDKN1B
Entrez GeneID
1027Protein Accession#
NP_004055.1Gene Name
CDKN1B
Gene Alias
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Description
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
Other Designations
cyclin-dependent kinase inhibitor 1B
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Interactome
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Pathway
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Disease
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Publication Reference
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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A.
Cancer Cell 2005 Jan; 7(1):51.
Application:IP, WB, Human, Mouse, HT-1080 cells, Mouse brains, Mouse fibroblasts, SKLMS-1, SKUT-1 cells.
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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
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