KLRK1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of KLRK1.
Immunogen
A synthetic peptide corresponding to human KLRK1.
Sequence
C-KVYSKEDQDLLK
Host
Goat
Theoretical MW (kDa)
25.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Flow Cytometry (10 ug/mL)
Western Blot (0.1-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
KLRK1 polyclonal antibody (Cat # PAB6828) staining (0.5 ug/mL) of MOLT-4 cell lysate (1) + peptide (2). (35 ug protein in RIPA buffer). Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
KLRK1 polyclonal antibody (Cat # PAB6828) Flow cytometric analysis of human peripheral blood monocytes. Primary incubation 30 minutes (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). -
Gene Info — KLRK1
Entrez GeneID
22914Protein Accession#
NP_0.31386.1Gene Name
KLRK1
Gene Alias
CD314, D12S2489E, FLJ17759, FLJ75772, KLR, NKG2-D, NKG2D
Gene Description
killer cell lectin-like receptor subfamily K, member 1
Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. [provided by RefSeq
Other Designations
NK cell receptor D|NKG2-D type II integral membrane protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Innate immune recognition and suppression of tumors.
Hayakawa Y, Smyth MJ.
Advances in Cancer Research 2006 Jan; 95:293.
Application:IHC-P, WB-Tr, PI, Human, Mouse, Human skin carcinoma, Mouse NK cells.
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Innate immune recognition and suppression of tumors.
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