SNAP25 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SNAP25.
Immunogen
A synthetic peptide corresponding to human SNAP25.
Sequence
C-DEANQRATKMLGSG
Host
Goat
Theoretical MW (kDa)
23.3, 23.3
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize both reported isoforms NP_003072 and NP_570824.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western blot (0.01-0.03 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SNAP25 polyclonal antibody (Cat # PAB6782) (0.03 ug/mL) staining of Mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SNAP25
Entrez GeneID
6616Protein Accession#
NP_003072.2;NP_570824.1Gene Name
SNAP25
Gene Alias
FLJ23079, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2
Gene Description
synaptosomal-associated protein, 25kDa
Omim ID
600322Gene Ontology
HyperlinkGene Summary
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030267|OTTHUMP00000030268|resistance to inhibitors of cholinesterase 4 homolog|synaptosomal-associated protein 25
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Interactome
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Pathway
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Disease
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Publication Reference
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Attention-deficit hyperactivity disorder (ADHD).
Voeller KK.
Journal of Child Neurology 2004 Oct; 19(10):798.
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Attention-deficit hyperactivity disorder (ADHD).
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