MAPT (phospho S214) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAPT.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S214 of human MAPT.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of extract from mouse brain tissue, using MAPT (phospho S214) polyclonal antibody (Cat # PAB5837). -
Gene Info — MAPT
Entrez GeneID
4137Gene Name
MAPT
Gene Alias
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, TAU
Gene Description
microtubule-associated protein tau
Gene Ontology
HyperlinkGene Summary
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq
Other Designations
G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein.
Smet C, Wieruszeski JM, Buee L, Landrieu I, Lippens G.
FEBS Letters 2005 Aug; 579(19):4159.
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Individual and regional variations of phospho-tau species in progressive supranuclear palsy.
Puig B, Rey MJ, Ferrer I.
Acta Neuropathologica 2005 Jun; 110(3):261.
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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.
Gotz J, Chen F, van Dorpe J, Nitsch RM.
Science 2001 Aug; 293(5534):1491.
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Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein.
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