CFL1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CFL1.
Immunogen
A synthetic peptide corresponding to residues surrounding S3 of human CFL1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of the extracts from COLO 205 cells using CFL1 polyclonal antibody (Cat # PAB5302) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CFL1 polyclonal antibody (Cat # PAB5302). -
Gene Info — CFL1
Entrez GeneID
1072Gene Name
CFL1
Gene Alias
CFL
Gene Description
cofilin 1 (non-muscle)
Omim ID
601442Gene Ontology
HyperlinkGene Summary
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Detection of urine cofilin-1 from patients hospitalized in the intensive care unit using the metal-enhanced fluorescence technique.
Chao CH, Chang YF, Chen HC, Lin LY, Yu PC, Chang YS, Lee YJ.
Sensors and Actuators B: Chemical 2010 Oct; 173:184.
Application:ELISA, Human, Urine from intensive care unit (ICU) patients.
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MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.
Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K.
The EMBO Journal 2006 Feb; 25(4):713.
Application:WB, Human, MSS31 cells, HUVECs.
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Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.
Wang Y, Shibasaki F, Mizuno K.
The Journal of Biological Chemistry 2005 Jan; 280(13):12683.
Application:WB-Tr, Human, HEK 293T, HeLa cells.
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Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer.
Smith-Beckerman DM, Fung KW, Williams KE, Auersperg N, Godwin AK, Burlingame AL.
Molecular & Cellular Proteomics 2004 Dec; 4(2):156.
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Detection of urine cofilin-1 from patients hospitalized in the intensive care unit using the metal-enhanced fluorescence technique.
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