KLK5 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of KLK5 polyclonal antibody (Cat # PAB4411) in mouse brain tissue lysate . KLK5 (arrow) was detected using the purified KLK5 polyclonal antibody (Cat # PAB4411) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KLK5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human KLK5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of KLK5 polyclonal antibody (Cat # PAB4411) in mouse brain tissue lysate . KLK5 (arrow) was detected using the purified KLK5 polyclonal antibody (Cat # PAB4411) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — KLK5
Entrez GeneID
25818Protein Accession#
NP_036559;Q9Y337Gene Name
KLK5
Gene Alias
KLK-L2, KLKL2, SCTE
Gene Description
kallikrein-related peptidase 5
Omim ID
605643Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
kallikrein 5|kallikrein-like protein 2|stratum corneum tryptic enzyme
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Interactome
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Disease
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Publication Reference
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KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, Lemarie E, Courty Y.
Biochemical and Biophysical Research Communications 2005 Apr; 329(4):1260.
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Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression.
Michael IP, Sotiropoulou G, Pampalakis G, Magklara A, Ghosh M, Wasney G, Diamandis EP.
The Journal of Biological Chemistry 2005 Apr; 280(15):14628.
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LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, Wakamatsu K, Ohtsubo S, Takahashi H, Hashimoto Y, Dopping-Hepenstal PJ, McGrath JA, Iizuka H, Richard G, Hovnanian A.
The Journal of Investigative Dermatology 2005 Feb; 124(2):360.
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KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
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