GDF2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The GDF2 polyclonal antibody (Cat # PAB3885) is used in Western blot to detect GDF2 in mouse liver tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GDF2 polyclonal antibody (Cat # PAB3885) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GDF2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human GDF2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The GDF2 polyclonal antibody (Cat # PAB3885) is used in Western blot to detect GDF2 in mouse liver tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GDF2 polyclonal antibody (Cat # PAB3885) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. -
Gene Info — GDF2
Entrez GeneID
2658Protein Accession#
Q9UK05Gene Name
GDF2
Gene Alias
BMP-9, BMP9
Gene Description
growth differentiation factor 2
Omim ID
605120Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. [provided by RefSeq
Other Designations
OTTHUMP00000019538|bone morphogenetic protein 9
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Disease
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Publication Reference
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Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis.
Li P, Li Y, Zhu L, Yang Z, He J, Wang L, Shang Q, Pan H, Wang H, Ma X, Li B, Fan X, Ge S, Jia R, Zhang H.
Biochimica et Biophysica Acta 2017 Dec; 1864(3):709.
Application：ELISA, Human, Human serum from patients with hepatic fibrosis.
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BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1.
Majumdar MK, Wang E, Morris EA.
Journal of Cellular Physiology 2001 Dec; 189(3):275.
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Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.
Lopez-Coviella I, Berse B, Krauss R, Thies RS, Blusztajn JK.
Science 2000 Jul; 289(5477):313.
Application：Treated, Recombinant protein.
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Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver.
Miller AF, Harvey SA, Thies RS, Olson MS.
The Journal of Biological Chemistry 2000 Jun; 275(24):17937.
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Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis.
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