BMPR1B polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BMPR1B polyclonal antibody (Cat # PAB3839) in NCI-H460 cell lysate (Lane A) and mouse heart tissue lysate (Lane B) . BMPR1B (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMPR1B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 472-502 of human BMPR1B.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA
Immunohistochemistry (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BMPR1B polyclonal antibody (Cat # PAB3839) in NCI-H460 cell lysate (Lane A) and mouse heart tissue lysate (Lane B) . BMPR1B (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BMPR1B
Entrez GeneID
658Protein Accession#
NP_001194Gene Name
BMPR1B
Gene Alias
ALK-6, ALK6, CDw293
Gene Description
bone morphogenetic protein receptor, type IB
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq
Other Designations
OTTHUMP00000161622|activin receptor-like kinase 6|serine/threonine receptor kinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Suring K, Majewski F, Tinschert S, Grzeschik KH, Muller D, Knaus P, Nurnberg P, Mundlos S.
PNAS 2003 Oct; 100(21):12277.
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Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
A K Astrom, D Jin, T Imamura, E Roijer, B Rosenzweig, K Miyazono, P ten Dijke, G Stenman.
Mammalian Genome 1999 Mar; 10(3):299.
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Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs.
Ide H, Katoh M, Sasaki H, Yoshida T, Aoki K, Nawa Y, Osada Y, Sugimura T, Terada M.
Oncogene 1997 Mar; 14(11):1377.
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Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
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