BMP1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue lysate (35 ug/lane) with BMP1 polyclonal antibody (Cat # PAB3670).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BMP1 polyclonal antibody (Cat # PAB3670) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMP1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human BMP1.
Host
Rabbit
Reactivity
Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue lysate (35 ug/lane) with BMP1 polyclonal antibody (Cat # PAB3670).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BMP1 polyclonal antibody (Cat # PAB3670) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — BMP1
Entrez GeneID
649Protein Accession#
P13497Gene Name
BMP1
Gene Alias
FLJ44432, PCOLC, PCP, TLD, pCP-2
Gene Description
bone morphogenetic protein 1
Omim ID
112264Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq
Other Designations
procollagen C-endopeptidase|procollagen C-proteinase
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Interactome
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Disease
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Publication Reference
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Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.
Leighton M, Kadler KE.
The Journal of Biological Chemistry 2003 May; 278(20):18478.
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Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity.
Hartigan N, Garrigue-Antar L, Kadler KE.
The Journal of Biological Chemistry 2003 Mar; 278(20):18045.
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Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.
Garrigue-Antar L, Hartigan N, Kadler KE.
The Journal of Biological Chemistry 2002 Nov; 277(45):43327.
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Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.
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