APP polyclonal antibody
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APP polyclonal antibody (Cat # PAB29064) was analyzed by immunohistochemical staining at a concentration of 3 ug/mL using fluorescein-labeled goat anti-chicken IgY at 1:500 dilution or HRP-labeled goat anti-chicken IgY at 1:2000 dilution as the secondary reagent.
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Specification
Product Description
Chicken polyclonal antibody raised against recombinant APP.
Immunogen
A KLH-conjugated synthetic peptide corresponding to residues 1-17 of the amyloid-beta peptide.
Sequence
DAEFRHDSGYEVHHQKL
Host
Chicken
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgY
Quality Control Testing
Immunohistochemistry
APP polyclonal antibody (Cat # PAB29064) was analyzed by immunohistochemical staining at a concentration of 3 ug/mL using fluorescein-labeled goat anti-chicken IgY at 1:500 dilution or HRP-labeled goat anti-chicken IgY at 1:2000 dilution as the secondary reagent.
Recommend Usage
Immunocytochemistry
Immunohistochemistry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% sodium azide)
Storage Instruction
Store at 4°C and avoid from light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
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Gene Info — APP
Entrez GeneID
351Gene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
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Interactome
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Disease
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