Products

Western Blot (Transfected lysate)

Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate).
Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with MFSD8 polyclonal antibody (Cat # PAB24363).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human kidney with MFSD8 polyclonal antibody (Cat # PAB24363) shows distinct cytoplasmic and membranous positivity in cells in tubules at 1:50-1:200 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with MFSD8 polyclonal antibody (Cat # PAB24363) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli and vesicles.

Entrez GeneID

256471

Protein Accession#

Q8NHS3

Gene Name

MFSD8

Gene Alias

CLN7, MGC33302

Gene Description

major facilitator superfamily domain containing 8

Omim ID

610951 611124

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq

Other Designations

ceroid-lipofuscinosis, neuronal 7, late infantile