GDNF polyclonal antibody
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of recombinant GDNF protein with GDNF polyclonal antibody (Cat # PAB19542).
Lane 1 : 10 ng
Lane 2 : 5 ng
Lane 3 : 2.5 ng
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin embedded rat brain tissue section with GDNF polyclonal antibody (Cat # PAB19542).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GDNF.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human GDNF.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
The synthetic peptide different from the related mouse sequence by three amino acids and rat sequence by two amino acids.
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of recombinant GDNF protein with GDNF polyclonal antibody (Cat # PAB19542).
Lane 1 : 10 ng
Lane 2 : 5 ng
Lane 3 : 2.5 ngImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin embedded rat brain tissue section with GDNF polyclonal antibody (Cat # PAB19542). -
Gene Info — GDNF
Entrez GeneID
2668Gene Name
GDNF
Gene Alias
ATF1, ATF2, HFB1-GDNF
Gene Description
glial cell derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq
Other Designations
astrocyte-derived trophic factor|glial cell line derived neurotrophic factor|glial derived neurotrophic factor
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Interactome
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Disease
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