BIRC5 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC5.
Immunogen
A synthetic peptide corresponding to residues surrounding T117 of human BIRC5.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to BIRC5.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from mouse lung cells, using BIRC5 polyclonal antibody (Cat # PAB18224).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BIRC5 polyclonal antibody (Cat # PAB18224).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using BIRC5 polyclonal antibody (Cat # PAB18224).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BIRC5
Entrez GeneID
332Protein Accession#
O15392Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway.
Fanling Meng, Jing Ding, Wei Xu, Chang Luo, Xihai Chen, Ruichun Zhang, Lin Sui, Yuanlong Hu, Shuang Liu, Guangyue Shi, Yunlong He, Xin Ning, Rong Ma, Ning Huang.
Translational Cancer Research 2022 Feb; 11(2):414.
Application:WB-Tr, Human, SKOV3 cells.
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Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Sillje HH, Sauer G, Nigg EA, Korner R.
PNAS 2006 Apr; 103(14):5391.
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Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells.
Zheng W, Ma X, Wei D, Wang T, Ma Y, Yang S.
DNA Sequence: the Journal of DNA Sequencing and Mapping 2005 Oct; 16(5):321.
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Identification of a novel splice variant of the human anti-apoptopsis gene survivin.
Badran A, Yoshida A, Ishikawa K, Goi T, Yamaguchi A, Ueda T, Inuzuka M.
Biochemical and Biophysical Research Communications 2004 Feb; 314(3):902.
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Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway.
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