ARRB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells, treated with Etoposide (25 uM, 60 mins), using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".
Immunofluorescence
Immunofluorescence analysis of A-549 cells, using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ARRB1.
Immunogen
A synthetic peptide corresponding to human ARRB1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to ARRB1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells, treated with Etoposide (25 uM, 60 mins), using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of A-549 cells, using ARRB1 polyclonal antibody (Cat # PAB18161).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARRB1
Entrez GeneID
408Protein Accession#
P49407Gene Name
ARRB1
Gene Alias
ARB1, ARR1
Gene Description
arrestin, beta 1
Omim ID
107940Gene Ontology
HyperlinkGene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq
Other Designations
arrestin 2|arrestin beta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain.
Lombardi MS, van den Tweel E, Kavelaars A, Groenendaal F, van Bel F, Heijnen CJ.
Stroke 2004 Apr; 35(4):981.
Application：WB, Rat, Rat brains.
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Analysis of the C-terminal tail of the rat thyrotropin-releasing hormone receptor-1 in interactions and cointernalization with beta-arrestin 1-green fluorescent protein.
Groarke DA, Drmota T, Bahia DS, Evans NA, Wilson S, Milligan G.
Molecular Pharmacology 2001 Feb; 59(2):375.
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Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain.
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