ADRB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRB2.
Immunogen
A synthetic peptide corresponding to C-terminus of human ADRB2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ADRB2.
Form
Liquid
Recommend Usage
Western Blot (1:500~1:1000)
Immunofluorescence (1:500~1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells, using ADRB2 polyclonal antibody (Cat # PAB18064).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of NIH/3T3 cells, using ADRB2 polyclonal antibody (Cat # PAB18064).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRB2
Entrez GeneID
154Protein Accession#
P07550Gene Name
ADRB2
Gene Alias
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Gene Description
adrenergic, beta-2-, receptor, surface
Gene Ontology
HyperlinkGene Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq
Other Designations
beta-2 adrenergic receptor|beta-2 adrenoceptor|catecholamine receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Norepinephrine and Epinephrine Enhanced the Infectivity of Enterovirus 71.
Liao YT, Wang SM, Wang JR, Yu CK, Liu CC.
PloS One 2015 Aug; 10(8):e0135154.
Application:Flow Cyt, IF, Human, A549, RD, SK-N-SH, HL-60, THP-1, Jurkat, hPBMC cells.
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Modulation of postendocytic sorting of G protein-coupled receptors.
Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M.
Science 2002 Jul; 297(5581):615.
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The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.
Moffett S, Rousseau G, Lagace M, Bouvier M.
Journal of Neurochemistry 2001 Jan; 76(1):269.
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A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.
Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M.
Nature 1999 Sep; 401(6750):286.
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Norepinephrine and Epinephrine Enhanced the Infectivity of Enterovirus 71.
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