ADRA1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRA1A.
Immunogen
A synthetic peptide corresponding to human ADRA1A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ADRA1A.
Form
Liquid
Recommend Usage
Immunofluorescence (1:500~1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of A-549 cells, using ADRA1A polyclonal antibody (Cat # PAB18063).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRA1A
Entrez GeneID
148Protein Accession#
P35348Gene Name
ADRA1A
Gene Alias
ADRA1C, ADRA1L1, ALPHA1AAR
Gene Description
adrenergic, alpha-1A-, receptor
Omim ID
104221Gene Ontology
HyperlinkGene Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq
Other Designations
G protein coupled receptor|OTTHUMP00000125313|adrenergic, alpha -1A-, receptor|adrenergic, alpha-1A-, receptor variant 1|adrenergic, alpha-1A-, receptor variant 3|adrenergic, alpha-1A-, receptor variant 5|adrenergic, alpha-1A-, receptor variant 8|adrenerg
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Publication Reference
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Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.
Weinberg DH, Trivedi P, Tan CP, Mitra S, Perkins-Barrow A, Borkowski D, Strader CD, Bayne M.
Biochemical and Biophysical Research Communications 1994 Jun; 201(3):1296.
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The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.
Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, et al..
Molecular Pharmacology 1994 Apr; 45(4):703.
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Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.
Hirasawa A, Horie K, Tanaka T, Takagaki K, Murai M, Yano J, Tsujimoto G.
Biochemical and Biophysical Research Communications 1993 Sep; 195(2):902.
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Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.
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