ACO1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACO1.
Immunogen
A synthetic peptide corresponding to human ACO1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ACO1.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50~1:100)
IELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using ACO1 polyclonal antibody (Cat # PAB18048).
Peptide "+" means "with peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACO1
Entrez GeneID
48Protein Accession#
P21399Gene Name
ACO1
Gene Alias
ACONS, IREB1, IREBP, IREBP1, IRP1
Gene Description
aconitase 1, soluble
Omim ID
100880Gene Ontology
HyperlinkGene Summary
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq
Other Designations
OTTHUMP00000021176|OTTHUMP00000021177|OTTHUMP00000045233|aconitase 1|aconitate hydratase|citrate hydro-lyase|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Glyoxylate and dicarboxylate metabolism
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Publication Reference
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Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
Hirling H, Emery-Goodman A, Thompson N, Neupert B, Seiser C, Kuhn LC.
Nucleic Acids Research 1992 Jan; 20(1):33.
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Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
Hentze MW, Argos P.
Nucleic Acids Research 1991 Apr; 19(8):1739.
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Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.
Rouault TA, Tang CK, Kaptain S, Burgess WH, Haile DJ, Samaniego F, McBride OW, Harford JB, Klausner RD.
PNAS 1990 Oct; 87(20):7958.
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Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
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