PIKFYVE polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIKFYVE.
Immunogen
A synthetic peptide corresponding to internal of human PIKFYVE.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This detects endogenous levels of total PIKFYVE protein.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PIKFYVE polyclonal antibody (Cat # PAB17315).
Peptide "+" means "with peptide blocking". -
Gene Info — PIP5K3
Entrez GeneID
200576Protein Accession#
Q9Y2I7Gene Name
PIP5K3
Gene Alias
CFD, FAB1, KIAA0981, MGC40423, PIKFYVE, PIP5K
Gene Description
phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
Gene Ontology
HyperlinkGene Summary
PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. Signaling by phosphorylated species of phosphatidylinositol regulates diverse cellular processes, including membrane trafficking and cytoskeletal reorganization (Shisheva et al., 1999 [PubMed 9858586]).[supplied by OMIM
Other Designations
1-phosphatidylinositol-4-phosphate 5-kinase|FYVE finger-containing phosphoinositide kinase|OTTHUMP00000163872|PtdIns(4)P-5-kinase|phosphatidylinositol-3-phosphate 5-kinase type III|phosphatidylinositol-4-phosphate 5-kinase, type III
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans.
Hairfield ML, Westwater C, Dolan JW.
Microbiology 2002 Jun; 148(Pt 6):1737.
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skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release.
Hassan BA, Prokopenko SN, Breuer S, Zhang B, Paululat A, Bellen HJ.
Genetics 1998 Dec; 150(4):1527.
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Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.
Davis JN, Rock CO, Cheng M, Watson JB, Ashmun RA, Kirk H, Kay RJ, Roussel MF.
Molecular and Cellular Biology 1997 Dec; 17(12):7398.
Application:WB-Tr, Human, COS-7 cells.
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Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans.
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