AAK1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
AAK1 polyclonal antibody (Cat # PAB17258) (1 ug/mL) staining of human amygdala lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AAK1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human AAK1.
Sequence
C-GSPRTSQQNVYNPSE
Host
Goat
Theoretical MW (kDa)
104
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
AAK1 polyclonal antibody (Cat # PAB17258) (1 ug/mL) staining of human amygdala lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AAK1
Entrez GeneID
22848Protein Accession#
NP_055726.3Gene Name
AAK1
Gene Alias
DKFZp686F03202, DKFZp686K16132, FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, KIAA1048, MGC138170, MGC164568, MGC164570
Gene Description
AP2 associated kinase 1
Gene Ontology
HyperlinkGene Summary
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
adaptor-associated kinase 1
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Interactome
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Disease
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Publication Reference
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A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.
Henderson DM, Conner SD.
Molecular Biology of the Cell 2007 May; 18(7):2698.
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A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.
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