FGFR1 (phospho Y154) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using FGFR1 (phospho Tyr154) polyclonal antibody (Cat # PAB16969).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of FGFR1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y154 of human FGFR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of FGFR1 only when phosphorylated at tyrosine 154.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using FGFR1 (phospho Tyr154) polyclonal antibody (Cat # PAB16969).Enzyme-linked Immunoabsorbent Assay
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Gene Info — FGFR1
Entrez GeneID
2260Protein Accession#
P11362Gene Name
FGFR1
Gene Alias
BFGFR, CD331, CEK, FGFBR, FLG, FLJ99988, FLT2, HBGFR, KAL2, N-SAM
Gene Description
fibroblast growth factor receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
FMS-like tyrosine kinase 2|OTTHUMP00000190874|OTTHUMP00000190878|OTTHUMP00000190879|OTTHUMP00000190881|basic fibroblast growth factor receptor 1|fms-related tyrosine kinase 2|fms-related tyrosine kinase-2|heparin-binding growth factor receptor|hydroxyaryl
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer Xenografts with FGFR and ALK Kinase Inhibitors.
Ivana Peran, Eveline E Vietsch, Gai Yan, Anna T Riegel, Anton Wellstein.
Cancers 2022 Mar; 14(6):1517.
Application：IHC-P, Human, COLO357PL cells.
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Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer.
Golfmann K, Meder L, Koker M, Volz C, Borchmann S, Tharun L, Dietlein F, Malchers F, Florin A, Büttner R, Rosen N, Rodrik-Outmezguine V, Hallek M, Ullrich RT.
Oncogene 2018 Jul; [Epub].
Application：IHC-P, Human, Breast tumors.
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Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma.
Lehnen NC, von Massenhausen A, Kalthoff H, Zhou H, Glowka T, Schutte U, Holler T, Riesner K, Boehm D, Merkelbach-Bruse S, Kirfel J, Perner S, Gutgemann I.
Histopathology 2013 Aug; 63(2):157.
Application：IHC-P, Human, Pancreatic.
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Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.
Hinsby AM, Olsen JV, Bennett KL, Mann M.
Molecular & Cellular Proteomics 2003 Jan; 2(1):29.
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The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L.
Molecular Biology of the Cell 2002 Aug; 13(8):2881.
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Fibroblast growth factors, their receptors and signaling.
Powers CJ, McLeskey SW, Wellstein A.
Endocrine-Related Cancer 2000 Sep; 7(3):165.
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Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer Xenografts with FGFR and ALK Kinase Inhibitors.
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