FOS polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Lane 1 : MM453 whole cell lysate.
Lane 2 : MM231 whole cell lysate.
Lane 3 : HeLa whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo320 whole cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOS.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human FOS.
Host
Rabbit
Theoretical MW (kDa)
40.6
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Lane 1 : MM453 whole cell lysate.
Lane 2 : MM231 whole cell lysate.
Lane 3 : HeLa whole cell lysate.
Lane 4 : HT1080 whole cell lysate.
Lane 5 : Colo320 whole cell lysate. -
Gene Info — FOS
Entrez GeneID
2353Gene Name
FOS
Gene Alias
AP-1, C-FOS
Gene Description
v-fos FBJ murine osteosarcoma viral oncogene homolog
Omim ID
164810Gene Ontology
HyperlinkGene Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq
Other Designations
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|activator protein 1|cellular oncogene c-fos
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Interactome
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Pathway
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Disease
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Publication Reference
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miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M.
Aging Cell 2020 Mar; 19(3):e13118.
Application：WB-Ce, WB-Ti, Mouse, Mouse brains, Primary hippocampal cultures.
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Fos and bone cell development: lessons from a nuclear oncogene.
Grigoriadis AE, Wang ZQ, Wagner EF.
Trends in Genetics 1995 Nov; 11(11):436.
Application：IF, IHC, Mouse, Mouse bone tissues.
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c-fos is required for malignant progression of skin tumors.
Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM.
Cell 1995 Sep; 82(5):721.
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Human c-fos oncogene mapped within chromosomal region 14q21----q31.
Barker PE, Rabin M, Watson M, Breg WR, Ruddle FH, Verma IM.
PNAS 1984 Sep; 81(18):5826.
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miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
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